This article describes a numerical and experimental investigation of turbulent flow in pipes with periodic “d-type” corrugations. Four geometric configurations of d-type corrugated surfaces with different groove heights and lengths are evaluated, and calculations for Reynolds numbers ranging from 5000 to 100,000 are performed. The numerical analysis is carried out using computational fluid dynamics, and two turbulence models are considered: the two-equation, low-Reynolds-number Chen–Kim $k-\epsilon $ turbulence model, for which several flow properties such as friction factor, Reynolds stress, and turbulence kinetic energy are computed, and the algebraic LVEL model, used only to compute the friction factors and a velocity magnitude profile for comparison. An experimental loop is designed to perform pressure-drop measurements of turbulent water flow in corrugated pipes for the different geometric configurations. Pressure-drop values are correlated with the friction factor to validate the numerical results. These show that, in general, the magnitudes of all the flow quantities analyzed increase near the corrugated wall and that this increase tends to be more significant for higher Reynolds numbers as well as for larger grooves. According to previous studies, these results may be related to enhanced momentum transfer between the groove and core flow as the Reynolds number and groove length increase. Numerical friction factors for both the Chen–Kim $k-\epsilon $ and LVEL turbulence models show good agreement with the experimental measurements.