We present reduced-order models of unsteady low-Mach-number ideal gas flows in two-dimensional rectangular microchannels subject to first-order slip-boundary conditions. The pressure and density are related by a polytropic process, allowing for isothermal or isentropic flow assumptions. The Navier–Stokes equations are simplified using low-Mach-number expansions of the pressure and velocity fields. Up to first order, this approximation results in a system that is subject to no-slip condition at the solid boundary. The second-order system satisfies the slip-boundary conditions. The resulting equations and the subsequent pressure-flow-rate relationships enable modeling the flow using analog circuit components. The accuracy of the proposed models is investigated for steady and unsteady flows in a two-dimensional channel for different values of Mach and Knudsen numbers.