The effects of the pressure gradient and surface roughness on turbulent boundary layers have been experimentally investigated. In Part I, smooth- and rough-surface turbulent boundary layers with and without favorable pressure gradients (FPG) are presented. All of the tests have been conducted at the same Reynolds number (based on the length of the flat plate) of 900,000. Streamwise time-mean and fluctuating velocities have been measured using a single-sensor hot-wire probe. For smooth surfaces, the FPG decreases the mean velocity defect and increases the wall shear stress; however, the friction coefficient hardly changes due to the increased freestream velocity. The FPG effect on the streamwise normal Reynolds stress has been examined. The FPG increases the streamwise normal Reynolds stress for y less than 0.6 times the boundary layer thickness. With the zero pressure gradient (ZPG), the roughness increases the mean velocity defect throughout the boundary layer and increases the normal Reynolds stress for y greater than twice the average roughness height. The roughness effect on the mean velocity defect is stronger under the FPG than under the ZPG for y less than 30 times the average roughness height. For y less than 25 times the average roughness height, the roughness effect of increasing normal Reynolds stress is also stronger under the FPG than under the ZPG. Consequently, for a rough surface, the FPG increases the integrated streamwise turbulent kinetic energy, friction coefficient, roughness Reynolds number, and roughness shift. Furthermore, the FPG increases the roughness effects on the integral boundary layer parameters—the boundary layer thickness, momentum thickness, ratio of the displacement thickness to the boundary layer thickness, and shape factor. Thus, the FPG augments the roughness effects on turbulent boundary layers.