Stratified and annular gas–liquid flow patterns are commonly encountered in many industrial applications, such as oil and gas transportation pipelines, heat exchangers, and process equipment. The measurement and visualization of two-phase flow characteristics are of great importance as two-phase flows persist in many fluids engineering applications. A wire-mesh sensor (WMS) technique based on conductance measurements has been applied to investigate two-phase horizontal pipe flow. The horizontal flow test section consisting of a 76.2 mm ID pipe, 18 m long was employed to generate stratified and annular flow conditions. Two 16 × 16 wire configuration sensors, installed 17 m from the inlet of the test section, are used to determine the void fraction within the cross section of the pipe and determine interface velocities between the gas and liquid. These physical flow parameters were extracted using signal processing and cross-correlation techniques. In this work, the principle of WMS and the methodology of flow parameter extraction are described. From the obtained raw data time series of void fraction, cross-sectional mean void fraction, time averaged void fraction profiles, interfacial structures, and velocities of the periodic structures are determined for different liquid and gas superficial velocities that ranged from 0.03 m/s to 0.2 m/s and from 9 m/s to 34 m/s, respectively. The effects of liquid viscosity on the measured parameters have also been investigated using three different viscosities.