The blade trailing edge profile is of crucial importance for the performance and pressure pulsations of centrifugal pumps. In the present study, numerical investigation is conducted to analyze the effect of the blade trailing edge profile influencing the performance and unsteady pressure pulsations in a low specific speed centrifugal pump. Five typical blade trailing edges are analyzed including original trailing edge (OTE), circle edge (CE), ellipse on pressure side (EPS), ellipse on suction side (ESS), and ellipse on both sides (EBS). Results show that the well-designed blade trailing edges, especially for the EPS and EBS profiles, can significantly improve the pump efficiency. Pressure amplitudes at fBPF and 2fBPF are together calculated to evaluate the influence of the blade trailing edge profile on pressure pulsations. The EPS and EBS profiles contribute obviously to pressure pulsations reduction. In contrast, the CE and ESS profiles lead to increase of pressure pulsation amplitude compared with the OTE pump. Vorticity distribution at the blade trailing edge demonstrates that the EPS and EBS profiles have an effective impact on reducing vortex intensity at the blade trailing edge. Consequently, rotor–stator interaction could be attenuated leading to lower pressure pulsation amplitude. It is thought to be the main reason of pressure pulsations reduction obtained with the proper modified blade trailing edges. The results would pave the way for further optimization of the blade trailing edge profile.