Flows over airfoils and blades in rotating machinery for unmanned and microaerial vehicles, wind turbines, and propellers consist of different flow regimes. A laminar boundary layer near the leading edge is often followed by a laminar separation bubble with a shear layer on top of it that experiences transition to turbulence. The separated turbulent flow then reattaches and evolves downstream from a nonequilibrium turbulent boundary layer to an equilibrium one. Typical Reynolds-averaged Navier–Stokes (RANS) turbulence modeling methods were shown to be inadequate for such laminar separation bubble flows (Spalart and Strelets, 2000, “Mechanisms of Transition and Heat Transfer in a Separation Bubble,” J. Fluid Mech., 403, pp. 329–349). Direct numerical simulation (DNS) is the most reliable but is also the most computationally expensive alternative. This work assesses the capability of large eddy simulations (LES) to reduce the resolution requirements for such flows. Flow over a flat plate with suitable velocity boundary conditions away from the plate to produce a separation bubble is considered. Benchmark DNS data for this configuration are generated with the resolution of 59 × 106 mesh points; also used is a different DNS database with 15 × 106 points (Spalart and Strelets, 2000, “Mechanisms of Transition and Heat Transfer in a Separation Bubble,” J. Fluid Mech., 403, pp. 329–349). Results confirm that accurate LES are possible using O(1%) of the DNS resolution.