The J750 PolyJet printer is the newest model of full-color, multi-material 3D printer from Stratasys. Currently, limited information is available about the effects of control factors on mechanical properties such as elastic modulus, ultimate tensile strength, and elongation. In this study, the effects of two control factors, orientation and layer thickness, on mechanical properties of samples printed by the Stratasys J750 printer are investigated. The results show that orientation significantly affects mechanical properties. Specifically, samples printed with its axial direction parallel to the direction of printing have the highest elastic modulus, and elongation, whereas samples printed with its axial direction perpendicular to the direction of printing have the highest ultimate tensile strength. Also, layer thickness makes a significant difference for mechanical properties, and larger layer thickness leads to higher ultimate tensile strength and elongation. These results would be valuable to researchers and practitioners who use J750.