Hemodynamics plays an important role in cardiovascular physiology and pathology. Pulsatile flow (Q), pressure (P), and diameter (D) waveforms exert wall shear stress (WSS), normal stress, and circumferential strain (CS) on blood vessels. Most in vitro studies to date have focused on either WSS or CS but not their interaction. Recently, we have shown that concomitant WSS and CS affect EC biochemical response modulated by the temporal phase angle between WSS and CS (stress phase angle, SPA). Large negative SPA has been shown to occur in regions of the circulation where atherosclerosis and intimal hyperplasia are prevalent. Here, we report that nitric oxide (NO) biochemical secretion was significantly decreased in response to a large negative SPA of −180 deg with respect to an SPA of 0° in bovine aortic endothelial cells (BAEC) at 5 h. A new hemodynamic simulator for the study of the physiologic SPA was used to provide the hemodynamic conditions of pro-atherogenic (SPA=−180 deg) and normopathic (SPA=0 deg) states. The role of complex hemodynamics in vascular remodeling, homeostasis, and pathogenesis can be advanced by further assessment of the hypothesis that a large negative SPA is pro-atherogenic.
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June 2006
Technical Papers
Large Negative Stress Phase Angle (SPA) Attenuates Nitric Oxide Production in Bovine Aortic Endothelial Cells
Michael B. Dancu,
Michael B. Dancu
Biomolecular Transport Dynamics Laboratory, Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802
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John M. Tarbell
John M. Tarbell
Department of Biomedical Engineering, The City University of New York, NY 10031
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Michael B. Dancu
Biomolecular Transport Dynamics Laboratory, Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802
John M. Tarbell
Department of Biomedical Engineering, The City University of New York, NY 10031
Contributed by the Bioengineering Division of ASME for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received December 8, 2003; final manuscript received May 12, 2004. Review conducted by Philip V. Bayly.
J Biomech Eng. Jun 2006, 128(3): 329-334 (6 pages)
Published Online: May 15, 2006
Article history
Received:
December 8, 2003
Revised:
May 12, 2004
Online:
May 15, 2006
Citation
Dancu, M. B., and Tarbell, J. M. (May 15, 2006). "Large Negative Stress Phase Angle (SPA) Attenuates Nitric Oxide Production in Bovine Aortic Endothelial Cells ." ASME. J Biomech Eng. June 2006; 128(3): 329–334. https://doi.org/10.1115/1.1824120
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