Shear stress plays a pivotal role in pathogenesis of coronary heart disease. The spatial and temporal variation in hemodynamics of blood flow, especially shear stress, is dominated by the vessel geometry. The goal of the present study was to investigate the effect of 2D and 3D geometries on the numerical modeling of coronary blood flow and shear stress distribution. We developed physiologically realistic 2D and 3D models (with similar geometries) of the human left coronary artery under normal and stenosis conditions (30%, 60%, and 80%) using PROE (WF 3). Transient blood flows in these models were solved using laminar and turbulent models using a computational fluid dynamics solver, FLUENT (v6.3.26). As the stenosis severity increased, both models predicted a similar pattern of increased shear stress at the stenosis throat, and in recirculation zones formed downstream of the stenosis. The 2D model estimated a peak shear stress value of 0.91, 2.58, 5.21, and 10.09 Pa at the throat location under normal, 30%, 60%, and 80% stenosis severity. The peak shear stress values at the same location estimated by the 3D model were 1.41, 2.56, 3.15, and 13.31 Pa, respectively. The 2D model underestimated the shear stress distribution inside the recirculation zone compared with that of 3D model. The shear stress estimation between the models diverged as the stenosis severity increased. Hence, the 2D model could be sufficient for analyzing coronary blood flow under normal conditions, but under disease conditions (especially 80% stenosis) the 3D model was more suitable.
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e-mail: wei.yin@okstate.edu
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June 2010
Research Papers
Effect of Geometrical Assumptions on Numerical Modeling of Coronary Blood Flow Under Normal and Disease Conditions
Saravan Kumar Shanmugavelayudam,
Saravan Kumar Shanmugavelayudam
School of Mechanical and Aerospace Engineering,
Oklahoma State University
, Stillwater, OK 74078-5016
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David A. Rubenstein,
David A. Rubenstein
School of Mechanical and Aerospace Engineering,
Oklahoma State University
, Stillwater, OK 74078-5016
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Wei Yin
Wei Yin
Assistant Professor
School of Mechanical and Aerospace Engineering,
e-mail: wei.yin@okstate.edu
Oklahoma State University
, Stillwater, OK 74078-5016
Search for other works by this author on:
Saravan Kumar Shanmugavelayudam
School of Mechanical and Aerospace Engineering,
Oklahoma State University
, Stillwater, OK 74078-5016
David A. Rubenstein
School of Mechanical and Aerospace Engineering,
Oklahoma State University
, Stillwater, OK 74078-5016
Wei Yin
Assistant Professor
School of Mechanical and Aerospace Engineering,
Oklahoma State University
, Stillwater, OK 74078-5016e-mail: wei.yin@okstate.edu
J Biomech Eng. Jun 2010, 132(6): 061004 (8 pages)
Published Online: April 21, 2010
Article history
Received:
November 2, 2009
Revised:
January 8, 2010
Posted:
January 18, 2010
Published:
April 21, 2010
Online:
April 21, 2010
Citation
Shanmugavelayudam, S. K., Rubenstein, D. A., and Yin, W. (April 21, 2010). "Effect of Geometrical Assumptions on Numerical Modeling of Coronary Blood Flow Under Normal and Disease Conditions." ASME. J Biomech Eng. June 2010; 132(6): 061004. https://doi.org/10.1115/1.4001033
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