Recent applications of computational fluid dynamics (CFD) applied to the cardiovascular system have demonstrated its power in investigating the impact of hemodynamics on disease initiation, progression, and treatment outcomes. Flow metrics such as pressure distributions, wall shear stresses (WSS), and blood velocity profiles can be quantified to provide insight into observed pathologies, assist with surgical planning, or even predict disease progression. While numerous studies have performed simulations on clinical human patient data, it often lacks prediagnosis information and can be subject to large intersubject variability, limiting the generalizability of findings. Thus, animal models are often used to identify and manipulate specific factors contributing to vascular disease because they provide a more controlled environment. In this review, we explore the use of CFD in animal models in recent studies to investigate the initiating mechanisms, progression, and intervention effects of various vascular diseases. The first section provides a brief overview of the CFD theory and tools that are commonly used to study blood flow. The following sections are separated by anatomical region, with the abdominal, thoracic, and cerebral areas specifically highlighted. We discuss the associated benefits and obstacles to performing CFD modeling in each location. Finally, we highlight animal CFD studies focusing on common surgical treatments, including arteriovenous fistulas (AVF) and pulmonary artery grafts. The studies included in this review demonstrate the value of combining CFD with animal imaging and should encourage further research to optimize and expand upon these techniques for the study of vascular disease.
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August 2018
Review Articles
Computational Fluid Dynamics of Vascular Disease in Animal Models
Andrea Acuna,
Andrea Acuna
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: aacuna@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: aacuna@purdue.edu
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Alycia G. Berman,
Alycia G. Berman
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: berman1@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: berman1@purdue.edu
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Frederick W. Damen,
Frederick W. Damen
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: fdamen@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: fdamen@purdue.edu
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Brett A. Meyers,
Brett A. Meyers
School of Mechanical Engineering,
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: meyers18@purdue.edu
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: meyers18@purdue.edu
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Amelia R. Adelsperger,
Amelia R. Adelsperger
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jacks228@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jacks228@purdue.edu
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Kelsey C. Bayer,
Kelsey C. Bayer
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kbayer@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kbayer@purdue.edu
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Melissa C. Brindise,
Melissa C. Brindise
School of Mechanical Engineering,
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: mbrindis@purdue.edu
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: mbrindis@purdue.edu
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Brittani Bungart,
Brittani Bungart
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: bbungart@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: bbungart@purdue.edu
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Alexander M. Kiel,
Alexander M. Kiel
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: amkiel@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: amkiel@purdue.edu
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Rachel A. Morrison,
Rachel A. Morrison
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: morri107@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: morri107@purdue.edu
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Joseph C. Muskat,
Joseph C. Muskat
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jmuskat@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jmuskat@purdue.edu
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Kelsey M. Wasilczuk,
Kelsey M. Wasilczuk
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kwasilcz@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kwasilcz@purdue.edu
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Yi Wen,
Yi Wen
Department of Agricultural and Biological Engineering,
Purdue University,
225 South University Street,
West Lafayette, IN 47907
e-mail: wen16@purdue.edu
Purdue University,
225 South University Street,
West Lafayette, IN 47907
e-mail: wen16@purdue.edu
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Jiacheng Zhang,
Jiacheng Zhang
School of Mechanical Engineering,
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: zhan1589@purdue.edu
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: zhan1589@purdue.edu
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Patrick Zito,
Patrick Zito
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: pzito@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: pzito@purdue.edu
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Craig J. Goergen
Craig J. Goergen
ASME Membership
Bioengineering Division,
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: cgoergen@purdue.edu
Bioengineering Division,
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: cgoergen@purdue.edu
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Andrea Acuna
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: aacuna@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: aacuna@purdue.edu
Alycia G. Berman
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: berman1@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: berman1@purdue.edu
Frederick W. Damen
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: fdamen@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: fdamen@purdue.edu
Brett A. Meyers
School of Mechanical Engineering,
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: meyers18@purdue.edu
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: meyers18@purdue.edu
Amelia R. Adelsperger
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jacks228@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jacks228@purdue.edu
Kelsey C. Bayer
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kbayer@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kbayer@purdue.edu
Melissa C. Brindise
School of Mechanical Engineering,
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: mbrindis@purdue.edu
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: mbrindis@purdue.edu
Brittani Bungart
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: bbungart@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: bbungart@purdue.edu
Alexander M. Kiel
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: amkiel@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: amkiel@purdue.edu
Rachel A. Morrison
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: morri107@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: morri107@purdue.edu
Joseph C. Muskat
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jmuskat@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: jmuskat@purdue.edu
Kelsey M. Wasilczuk
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kwasilcz@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: kwasilcz@purdue.edu
Yi Wen
Department of Agricultural and Biological Engineering,
Purdue University,
225 South University Street,
West Lafayette, IN 47907
e-mail: wen16@purdue.edu
Purdue University,
225 South University Street,
West Lafayette, IN 47907
e-mail: wen16@purdue.edu
Jiacheng Zhang
School of Mechanical Engineering,
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: zhan1589@purdue.edu
Purdue University,
585 Purdue Mall,
West Lafayette, IN 47907
e-mail: zhan1589@purdue.edu
Patrick Zito
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: pzito@purdue.edu
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: pzito@purdue.edu
Craig J. Goergen
ASME Membership
Bioengineering Division,
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: cgoergen@purdue.edu
Bioengineering Division,
Weldon School of Biomedical Engineering,
Purdue University,
206 S. Martin Jischke Drive,
West Lafayette, IN 47907
e-mail: cgoergen@purdue.edu
1Corresponding author.
2These authors contributed equally to this work.
Manuscript received October 5, 2017; final manuscript received March 3, 2018; published online July 12, 2018. Assoc. Editor: Kristen Billiar.
J Biomech Eng. Aug 2018, 140(8): 080801 (14 pages)
Published Online: July 12, 2018
Article history
Received:
October 5, 2017
Revised:
March 3, 2018
Citation
Acuna, A., Berman, A. G., Damen, F. W., Meyers, B. A., Adelsperger, A. R., Bayer, K. C., Brindise, M. C., Bungart, B., Kiel, A. M., Morrison, R. A., Muskat, J. C., Wasilczuk, K. M., Wen, Y., Zhang, J., Zito, P., and Goergen, C. J. (July 12, 2018). "Computational Fluid Dynamics of Vascular Disease in Animal Models." ASME. J Biomech Eng. August 2018; 140(8): 080801. https://doi.org/10.1115/1.4039678
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