The purpose of this investigation was to analyze the impact of differential steering of a wheelchair with a pushrim on changes in the position of the body's center of gravity. The method assumed measuring the wheelchair trajectory and the body's center of gravity and determining the transverse relocation of the measured body's center of gravity in relation to a point on the wheelchair trajectory. Twenty-seven measurement tests which demonstrated various wheelchair trajectories were carried out within the investigation. The trajectories were 10 to 15 m long and involved moving forward (test 2), reversing (test 3), turning left (test 1) and right (test 4). The factor of deviation of the center of gravity of human body from the wheelchair trajectory was determined for selected characteristic turning maneuvers. The measured values ranged from 51 to 192 mm. The impact of the wheelchair trajectory on the position of the body's center of gravity was demonstrated as a result of this investigation. Consequently, a trajectory deviation factor for relocation of the human body weight on one side of the wheelchair has been demonstrated.