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1-11 of 11
Keywords: drug delivery
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Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2024, 146(10): 101001.
Paper No: BIO-23-1134
Published Online: May 13, 2024
...-mail: julianrey1009@gmail.com e-mail: tunais@radiology.ufl.edu e-mail: david.tran@med.usc.edu 1 Corresponding author. e-mail: msarnt@ufl.edu 18 04 2023 12 01 2024 13 05 2024 convection-enhanced delivery drug delivery AAV finite element computational model tumor...
Topics:
Biological tissues,
Brain,
Fluids,
Hydraulic conductivity,
Interpolation,
Materials properties,
Porosity,
Tumors,
Convection,
Computer simulation
Includes: Supplementary data
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2023, 145(6): 061007.
Paper No: BIO-22-1147
Published Online: March 8, 2023
..., pharynx, and larynx, as is the case with traditional inhalers [ 16 , 17 ]. Despite substantial research on drug delivery to the human respiratory tract for treating asthma and chronic obstructive pulmonary disease, inhaler device efficiency is still under study. The geometric design of inhaler devices...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2022, 144(11): 111003.
Paper No: BIO-21-1376
Published Online: June 16, 2022
...Jason N. Mehta; Brianna E. Morales; Fang-Chi Hsu; John H. Rossmeisl; Christopher G. Rylander Convection-enhanced delivery (CED) has been extensively studied for drug delivery to the brain due to its inherent ability to bypass the blood-brain barrier. Unfortunately, CED has also been shown...
Journal Articles
Coupled Porohyperelastic Mass Transport (PHEXPT) Finite Element Models for Soft Tissues Using ABAQUS
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2011, 133(4): 044502.
Published Online: February 18, 2011
... of in vivo tissues. Such FEMs will provide basic understanding of normal and pathological tissue responses and lead to optimization of local drug delivery strategies. We present a coupled porohyperelastic mass transport (PHEXPT) finite element approach developed using a commercially available ABAQUS finite...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. October 2010, 132(10): 101003.
Published Online: September 28, 2010
...R. A. Guha; N. H. Shear; M. Papini The impact and penetration of high speed particles with the human skin is of interest for targeted drug delivery by transdermal powder injection. However, it is often difficult to perform penetration experiments on dermal tissue using micron scale particles...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. July 2009, 131(7): 071007.
Published Online: July 16, 2009
... 2008 26 05 2009 16 07 2009 biological tissues biomedical MRI biotransport brain drug delivery systems neurophysiology convection-enhanced delivery (CED) diffusion tensor imaging (DTI) drug delivery computational fluid dynamics (CFD) mathematical modeling permeability...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074513.
Published Online: June 29, 2009
... pump out cytotoxic drugs from the intracellular space. In this study, we tested a hypothesis that freezing and thawing (F/T) may enhance intracellular drug delivery to MDR cancer cells via F/T-induced denaturation of MDR-associated proteins and/or membrane permeabilization. After a human MDR cancer...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2009, 131(2): 021010.
Published Online: December 10, 2008
... for the development of computational tools, e.g., for the optimization of intrathecal drug delivery and computer-aided evaluation of cerebral pathologies such as syrinx development in syringomelia. cerebrospinal fluid subarachnoid space porous media MRI drug delivery The cerebrospinal fluid (CSF...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2008, 130(1): 011015.
Published Online: February 20, 2008
...Frank E. Fresconi; Ajay K. Prasad The adverse health effects of inhaled particulate matter from the environment depend on its dispersion, transport, and deposition in the human airways. Similarly, precise targeting of deposition sites by pulmonary drug delivery systems also relies on characterizing...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 733–742.
Published Online: February 22, 2007
... of the diffusion coefficients in the polymer coating and in the wall. Concerning the strut apposition, it is shown that the fully embedded strut configuration would provide a better concentration distribution. 10 12 2006 22 02 2007 biodiffusion blood vessels drug delivery systems haemodynamics...
Journal Articles
Journal:
Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 722–732.
Published Online: February 18, 2007
... drug delivery Medical applications such as the administration of anesthesia, alternative modes of ventilation (such as high-frequency ventilation (HFV) ( 1 )), and clinical diagnoses of lung function ( 2 ) rely on an understanding of mass transport in the respiratory tract. Aerosol dispersion...