A preliminary two-dimensional (2D) numerical investigation of the active control of unsteady cavitation by means of one single synthetic jet actuator (SJA) is presented. The investigation involves the cloud-cavitating flow of water around a NACA 0015 hydrofoil with an angle of attack of 8-deg and ambient conditions. The SJA locates on the suction side at a distance of 16% of the chord from the leading edge; it has been modeled by means of a user-defined velocity boundary conditions based on a sinusoidal waveform. A Eulerian homogeneous mixture model has been used, coupled with an extended Schnerr–Sauer cavitation model and a volume of fluid interface tracking method. As first, a sensitivity analysis allowed to evaluate the influence of the main control parameters, namely, the momentum coefficient , the dimensionless frequency F+, and the jet angle αjet. As a result, the best performing SJA configuration was retrieved at , and , which led to a reduction of both the average vapor content and the average torsional load in the measure of 34.6% and 17.8%. The analysis of the coupled dynamics between vapor cavity–vorticity and their proper orthogonal decomposition (POD)-based modal structures highlighted the benefit of the SJA lies in preventing the growth of a thick sheet cavity, which causes the development of the highly cavitating cloud dynamics after the cavity breakup. This is mainly due to an additional vorticity close to the hydrofoil surface just downstream the SJA, as well as a local pressure modification close the SJA during the blowing stroke.