Optical molecular imaging is an emerging field, and high-resolution optical imaging of the distal lung parenchyma has been made possible with the advent of clinically approved fiber-based imaging modalities. However, currently, there is no single method of allowing the simultaneous imaging and delivery of targeted molecular imaging agents. The objective of this research is to create a catheterized device capable of fulfilling this need. We describe the rationale, development, and validation in ex vivo ovine lung to near clinical readiness of a triple lumen bronchoscopy catheter that allows concurrent imaging and fluid delivery, with the aim of clinical use to deliver multiple fluorescent compounds to image alveolar pathology. Using this device, we were able to produce high-quality images of bacterial infiltrates in ex vivo ovine lung within 60 s of instilling a single microdose of (<100 mcg) imaging agent. This has many advantages for future clinical usage over the current state of the art.
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September 2018
Design Innovation Paper
Development of an Alveolar Transbronchial Catheter for Concurrent Fiber Optics-Based Imaging and Fluid Delivery
Nathan Knighton,
Nathan Knighton
Department of Bioengineering,
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: nate.knighton@utah.edu
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: nate.knighton@utah.edu
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Brian Cottle,
Brian Cottle
Department of Bioengineering,
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: brian.k.cottle@utah.edu
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: brian.k.cottle@utah.edu
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Tom Vercauteren,
Tom Vercauteren
Wellcome/EPSRC Centre for Interventional and Surgical
Sciences,
University College London,
Charles Bell House 43-45 Foley Street,
London W1W 7TS, UK
e-mail: t.vercauteren@ucl.ac.uk
Sciences,
University College London,
Charles Bell House 43-45 Foley Street,
London W1W 7TS, UK
e-mail: t.vercauteren@ucl.ac.uk
Search for other works by this author on:
Ahsan Akram,
Ahsan Akram
EPSRC Proteus Hub,
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: ahsan.akram@ed.ac.uk
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: ahsan.akram@ed.ac.uk
Search for other works by this author on:
Annya Bruce,
Annya Bruce
EPSRC Proteus Hub,
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Annya.Bruce@ed.ac.uk
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Annya.Bruce@ed.ac.uk
Search for other works by this author on:
Kevin Dhaliwal,
Kevin Dhaliwal
EPSRC Proteus Hub,
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Kev.Dhaliwal@ed.ac.uk
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Kev.Dhaliwal@ed.ac.uk
Search for other works by this author on:
Robert Hitchcock
Robert Hitchcock
Department of Bioengineering,
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: r.hitchcock@utah.edu
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: r.hitchcock@utah.edu
Search for other works by this author on:
Nathan Knighton
Department of Bioengineering,
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: nate.knighton@utah.edu
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: nate.knighton@utah.edu
Brian Cottle
Department of Bioengineering,
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: brian.k.cottle@utah.edu
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: brian.k.cottle@utah.edu
Veronique Dentan
Tom Vercauteren
Wellcome/EPSRC Centre for Interventional and Surgical
Sciences,
University College London,
Charles Bell House 43-45 Foley Street,
London W1W 7TS, UK
e-mail: t.vercauteren@ucl.ac.uk
Sciences,
University College London,
Charles Bell House 43-45 Foley Street,
London W1W 7TS, UK
e-mail: t.vercauteren@ucl.ac.uk
Ahsan Akram
EPSRC Proteus Hub,
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: ahsan.akram@ed.ac.uk
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: ahsan.akram@ed.ac.uk
Annya Bruce
EPSRC Proteus Hub,
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Annya.Bruce@ed.ac.uk
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Annya.Bruce@ed.ac.uk
Kevin Dhaliwal
EPSRC Proteus Hub,
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Kev.Dhaliwal@ed.ac.uk
MRC Centre for Inflammation Research,
The Queen's Medical Research Institute,
The University of Edinburgh,
47 Little France Crescent,
Edinburgh EH16 4TJ, UK
e-mail: Kev.Dhaliwal@ed.ac.uk
Robert Hitchcock
Department of Bioengineering,
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: r.hitchcock@utah.edu
University of Utah,
36 S Wasatch Dr.,
Salt Lake City, UT 84112
e-mail: r.hitchcock@utah.edu
1Corresponding authors.
Manuscript received March 16, 2018; final manuscript received June 18, 2018; published online July 24, 2018. Assoc. Editor: Matthew R. Myers.
J. Med. Devices. Sep 2018, 12(3): 035003 (9 pages)
Published Online: July 24, 2018
Article history
Received:
March 16, 2018
Revised:
June 18, 2018
Citation
Knighton, N., Cottle, B., Dentan, V., Vercauteren, T., Akram, A., Bruce, A., Dhaliwal, K., and Hitchcock, R. (July 24, 2018). "Development of an Alveolar Transbronchial Catheter for Concurrent Fiber Optics-Based Imaging and Fluid Delivery." ASME. J. Med. Devices. September 2018; 12(3): 035003. https://doi.org/10.1115/1.4040639
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