Despite recognized as one key component for establishing a functional electrical connection with nerves, neural invasive peripheral interfaces are still not optimal for long-term applications in humans. An improvement in the field of biocompatible and non-toxic materials is necessary to overcome the issues of interface/tissue mismatch and physiological reactions. The present work aimed to study, implement and characterize a novel approach to modify the surface of neural mi-crolectrodes basedon polyimide thin films. The purpose was to improve biocompatibility and to promote neuronal migration, growth and differentiation by increasing the surface roughness and endowing the surface with structure-reactivity for thiol-containing amino acids or peptides. L-Cysteine-Rhodamine B, used as a model biomolecule, was successfully grafted on samples surface via the introduction of cross-linkable vinyl groups on polyimide foils. Preliminary in vitro biological analysis allowed to evaluate the tendency of PC12 cells to adhere and to proliferate.
Skip Nav Destination
Center for Micro-BioRobotics,
c/o Scuola Superiore Sant'Anna,
Department of Tissue Regeneration,
e-mail: p.wieringa@sssup.it
e-mail: a.cutrone@sssup.it
Article navigation
June 2013
Technical Briefs
Surface Modification of Polyimide Thin Films for Peripheral Invasive Neural Interfaces
S. Bossi,
S. Bossi
Senior Post-doctoral Fellow
e-mail: s.bossi@sssup.it
e-mail: s.bossi@sssup.it
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
Search for other works by this author on:
GL. Puleo,
GL. Puleo
Senior Post-doctoral Fellow
Center for Micro-BioRobotics,
c/o Scuola Superiore Sant'Anna,
e-mail: GianLuigi.Puleo@iit.it
Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
e-mail: GianLuigi.Puleo@iit.it
Search for other works by this author on:
G. Giudetti,
G. Giudetti
Senior Post-doctoral Fellow
Center for Micro-BioRobotics,
c/o Scuola Superiore Sant'Anna,
e-mail: guido.giudetti@sssup.it
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
e-mail: guido.giudetti@sssup.it
Search for other works by this author on:
P. Wieringa,
Center for Micro-BioRobotics,
c/o Scuola Superiore Sant'Anna,
Department of Tissue Regeneration,
e-mail: p.wieringa@sssup.it
P. Wieringa
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;MIRA Institute for Biomedical Technology and Technical Medicine
,Department of Tissue Regeneration,
University of Twente
,The Netherlands
e-mail: p.wieringa@sssup.it
Search for other works by this author on:
A. Cutrone,
e-mail: a.cutrone@sssup.it
A. Cutrone
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
e-mail: a.cutrone@sssup.it
Search for other works by this author on:
S. Micera
S. Micera
Professor Neural Engineering Area
Translational Neural Engineering Laboratory,
e-mail: s.micera@sssup.it
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;Translational Neural Engineering Laboratory,
Center for Neuroprosthetics and Institute of Bioengineering (IBI)-School of Engineering
,cole Polytechnique Fdrale de Lausanne (EPFL)
,Lausanne
, Switzerland
e-mail: s.micera@sssup.it
Search for other works by this author on:
M. Righi
e-mail: m.righi@sssup.it
S. Bossi
Senior Post-doctoral Fellow
e-mail: s.bossi@sssup.it
e-mail: s.bossi@sssup.it
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
GL. Puleo
Senior Post-doctoral Fellow
Center for Micro-BioRobotics,
c/o Scuola Superiore Sant'Anna,
e-mail: GianLuigi.Puleo@iit.it
Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
e-mail: GianLuigi.Puleo@iit.it
G. Giudetti
Senior Post-doctoral Fellow
Center for Micro-BioRobotics,
c/o Scuola Superiore Sant'Anna,
e-mail: guido.giudetti@sssup.it
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
e-mail: guido.giudetti@sssup.it
P. Wieringa
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;MIRA Institute for Biomedical Technology and Technical Medicine
,Department of Tissue Regeneration,
University of Twente
,The Netherlands
e-mail: p.wieringa@sssup.it
A. Cutrone
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
e-mail: a.cutrone@sssup.it
S. Micera
Professor Neural Engineering Area
Translational Neural Engineering Laboratory,
e-mail: s.micera@sssup.it
The BioRobotics Institute Scuola Superiore Sant'Anna
,Viale Rinaldo Piaggio 34
,56025 Potedera (PI)
, Italy
;Translational Neural Engineering Laboratory,
Center for Neuroprosthetics and Institute of Bioengineering (IBI)-School of Engineering
,cole Polytechnique Fdrale de Lausanne (EPFL)
,Lausanne
, Switzerland
e-mail: s.micera@sssup.it
Manuscript received March 13, 2013; final manuscript received April 30, 2013; published online June 17, 2013. Editor: Gerald E. Miller.
J. Med. Devices. Jun 2013, 7(2): 020937 (3 pages)
Published Online: June 17, 2013
Article history
Received:
March 13, 2013
Revision Received:
April 30, 2013
Citation
Righi, M., Bossi, S., Puleo, G., Giudetti, G., Wieringa, P., Cutrone, A., and Micera, S. (June 17, 2013). "Surface Modification of Polyimide Thin Films for Peripheral Invasive Neural Interfaces." ASME. J. Med. Devices. June 2013; 7(2): 020937. https://doi.org/10.1115/1.4024378
Download citation file:
Get Email Alerts
Cited By
Related Articles
Interaction of Asperities on Opposing Surfaces in Thin Film, Mixed Elastohydrodynamic Lubrication
J. Tribol (April,2008)
Limitations and Corrections of Optical Profilometry in Surface Characterization of Carbon Coated Magnetic Recording Disks
J. Tribol (October,1990)
Factors Affecting the Adhesion of Fluoropolymer Composites to Commercial Copper Foils
J. Electron. Packag (September,1993)
Two-Dimensional Transient Analysis of Absorbing Thin Films in Laser
Treatments
J. Heat Transfer (February,2000)
Related Proceedings Papers
Related Chapters
Insulating Properties of W-Doped Ga2O3 Films Grown on Si Substrate for Low-K Applications
International Conference on Advanced Computer Theory and Engineering, 4th (ICACTE 2011)
Optical Characterization of Low-Scatter, Plasma-Deposited Thin Films
Laser Induced Damage In Optical Materials: 1983
Digital Human in Engineering and Bioengineering Applications
Advances in Computers and Information in Engineering Research, Volume 1