Given the recent trend toward hybrid processing involving the integration of wire arc additive manufacturing (WAAM) and machining capabilities, this paper aims to identify and correlate microstructural variations observed in wire arc additively manufactured aluminum alloy 4043 workpieces to their specific micromilling responses. This is done with the explicit goal of assessing the feasibility of using micromilling responses to detect microstructural variations in WAAM workpieces. As part of this effort, variations in the interlayer cooling time are used to induce changes in the microstructure of a thin-wall WAAM workpiece. The microstructures are first characterized using in-process thermographic imaging, optical microscopy, polarized light microscopy, and indentation. Micromilling slotting experiments are then conducted on different regions within the workpiece. The findings suggest that cutting force signals are the premier candidate for in situ extraction of information regarding microstructural variations within WAAM workpieces. In particular, in situ analysis of the cutting force frequency spectrum can provide critical information regarding dominant failure mechanisms related to the underlying microstructure. Other key micromilling responses such as surface roughness, burr formation, and tool wear also correlate well with the underlying microstructural variations. While these early stage findings hold promise, future research efforts spanning multiple metal alloys systems and micromachining processes are needed to mature the proposed concept.