The experimental analysis is arranged to evaluate the thermal hydraulic performance on nanofluid flow in helical screw insert with tube at a number of strips and different twist ratios in laminar flow regime. The single strip (SS) helical screw inserts are also compared with the double strip (DS) helical screw inserts. The heat transfer enhancement is achieved with nanofluid flow in double strip as compared with single strip helical screw insert at decreased values of twist ratio and increased values of Reynolds number. A maximum enhancement of 421% is found in the value of Nusselt number with double strip helical screw insert at twist ratio of 1.5 and low value of Reynolds number in the flow of nanofluid than water in plain tube. The common correlations of Nusselt number and friction factor are generated. The thermal performance factor (TPF) is achieved at a maximum value of 2.42 with double strip than single strip helical screw inserts at twist ratio of 2.5 and low value of Reynolds number. The present analysis shows suitability of the double strip helical screw insert to enable miniaturization of the heat exchangers. A compact heat exchanger decreases the size of thermal application such as solar water heater, solar power plants, electronic cooling systems, radiator, etc., which could save environment by pollution reduction with utilization of energy.