...Jeff Bodner; Vikas Kaul The rising costs of clinical trials for medical devices in recent years has led to an increased interest in what are called in silico clinical trials, where simulation results are used to supplement or to replace those obtained from human patients. Here we present...

... uncertainties are larger than acceptable ranges for both simulation and experiment. Therefore, uncertainty reduction (UR) is important to achieve meaningful validation. A unique approach in this paper is to separate model error from uncertainty such that UR can reveal the model error. This paper aims to share...