Thermal, acoustic, and vibration loads are important to affect the strength and durability of many aerospace products, especially the compressor blades, solar wings, antennas, etc. In extreme cases, a strong acoustic load combined with vibration and thermal loads may cause blade fatigue damage or even failure. In the study, an experimental device is designed to simulate the thermo-acoustic-vibration comprehensive load. Based on the tested strain data, the response characteristics under the thermo-acoustic-vibration load are investigated experimentally. Besides, a finite element method (FEM) model considering the acoustic-vibration coupling and material parameters dependent on temperature is presented applying software ansys-workbench to calculate stress and strain frequency responses of the blades, and the results agree well with the experimental results. The work will help understand failure mechanism of aerospace products under a comprehensive load of thermo-acoustic-vibration.